|The RRM1 rrm1 (Catalog #MBS9403319) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The RRM1 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s RRM1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF).
Western blotting: 1:500 - 1:2000
Immunohistochemistry: 1:50 - 1:100
Immunofluorescence: 1:50 - 1:200. Researchers should empirically determine the suitability of the RRM1 rrm1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The RRM1 rrm1 product has the following accession number(s) (GI #4506749) (NCBI Accession #NP_001024.1) (Uniprot Accession #P23921). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the RRM1 Antibody with the following immunoassay(s):
Western Blot (WB) (Western blot analysis of extracts of various cell lines, using RRM1 antibody.)
Immunofluorescence (IF) (Immunofluorescence analysis of HeLa cell using RRM1 antibody. Blue: DAPI for nuclear staining.)
Ribonucleotide reductase catalyzes the rate-limiting step in the synthesis of deoxynucleotide triphosphates (dNTPs). The regulatory M1 subunit (RRM1) is present throughout the cell division cycle, but downregulated in quiescent cells (1). Research studies have demonstrated that RRM1 is involved in carcinogenesis and tumor progression, and its expression is correlated with resistance to chemotherapy in non-small cell lung cancer (2-4).
Immunogen Type: Recombinant Protein
Immunogen Description: Recombinant protein of human RRM1. Target Name: RRM1. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing RRM1 are readily searchable from our website. Different antibodies against the same target such as RRM1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Chromosome Aberrations, Disease Progression, Liver Diseases, Lung Neoplasms, Neoplasm Metastasis, Neoplasms, Experimental, Neutropenia, Ovarian Neoplasms are some of the diseases may be linked to RRM1 Antibody. RRM1 also interacts with the following gene(s): DUT, PCNA, RRM2, RRM2B. Blood, Brain, Liver, Lung, Lymph, Lymph Node, Muscle, Nerve, Pancreas, Vascular tissues are correlated with this protein. The following patways have been known to be associated with this gene.