anti-S6 antibody product blog
Tags: Antibody; Polyclonal Antibody; Ribosomal protein S6 kinase beta-2; anti-S6 antibody;
The S6 rps6kb2 (Catalog #MBS719433) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit anti-human Ribosomal protein S6 kinase beta-2 polyclonal Antibody, FITC reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s Ribosomal protein S6 kinase beta-2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA). Researchers should empirically determine the suitability of the S6 rps6kb2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.The S6 rps6kb2 product has the following accession number(s) (GI #55953117) (NCBI Accession #NP_003943.2) (Uniprot Accession #Q9UBS0). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Rabbit anti-human Ribosomal protein S6 kinase beta-2 polyclonal Antibody, FITC with the following immunoassay(s):
Western Blot
Acts to integrate nutrient and growth factor signals in regulation of protein synthesis, cell proliferation, cell growth, cell cycle progression and cell survival. Downstream effector of the mTOR signaling pathway. Phosphorylates specifically ribosomal protein S6 in response to insulin or several classes of mitogens. During translation initiation, the inactive form associatess with the eIF-3 complex under conditions of nutrient depletion. Mitogenic stimulation leads to phosphorylation and dissociation from the eIF-3 complex and the free activated form can phosphorylate other translational targets including EIF4B. Promotes protein synthesis by phosphorylating PDCD4 at \'Ser-67\' and targeting it for degradation. Phosphorylates RICTOR leading to regulation of mammalian target of rapamycin complex 2 (mTORC2) signaling; probably phosphorylates RICTOR at \'Thr-1135\'. Phosphorylates IRS1 at multiple serine residues coupled with insulin resistance; probably phosphorylates IRS1 at \'Ser-270\'. Required for TNF-alpha induced IRS-1 degradation. Phosphorylates EEF2K in response to IGF1 and inhibits EEF2K activity. Phosphorylates BAD at \'Ser-99\' in response to IGF1 leading to BAD inactivation and inhibition of BAD-induced apoptosis. Phosphorylates mitochondrial RMP leading to dissociation of a RMP:PPP1CC complex; probably phosphorylates RMP at \'Ser-99\'. The free mitochondrial PPP1CC can dephosphorylate RPS6KB1 at Thr-412 which is proposed to be a negative feed back mechanism for the RPS6KB1 antiapoptotic function. Phosphorylates GSK3B at \'Ser-9\' under conditions leading to loss of the TSC1-TSC2 complex. Phosphorylates POLDIP3.
Storage Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Conjugate: FITC. Immunogen: Recombinant human Ribosomal protein S6 kinase beta-2 protein
Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-9379 / sc-9381 / sc-130833.