|The SAP18 sap18 (Catalog #MBS643620) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The SAP18 (Histone Deacetylase Complex Subunit SAP18, 18kD Sin3-associated Polypeptide, 2HOR0202, Cell Growth-inhibiting Gene 38 Protein, Sin3-associated Polypeptide p18) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s SAP18 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunofluorescence (IF).
Suitable for use in Immunofluorescence and Western Blot.
Dilution: Immunofluorescence: 10ug/ml. Researchers should empirically determine the suitability of the SAP18 sap18 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The SAP18 sap18 product has the following accession number(s) (GI #48146187) (NCBI Accession #CAG33316.1) (Uniprot Accession #O00422). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful. The amino acid sequence is listed below:
MAVESRVTQE EIKKEPEKPI DREKTCPLLL RVFTTNNGRH HRMDEFSRGN VPSSELQIYT WMDATLKELT SLVKEVYPEA RKKGTHFNFA IVFTDVKRPG YRVKEIGSTM SGRKGTDDSM TLQSQKFQIG DYLDIAITPP NRAPPPSGRM RPY.
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Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter. A pseudogene has been identified on chromosome 2.
Immunogen: Full-length human SAP18, aa1-153 (NP_005861.1). In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing SAP18 are readily searchable from our website. Different antibodies against the same target such as SAP18 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. SAP18 also interacts with the following gene(s): ACIN1, HDAC1, RBBP4, RBBP7, RNPS1, SAP30, SIN3A, SUFU. The following patways have been known to be associated with this gene. Neoplasms are some of the diseases may be linked to SAP18 (Histone Deacetylase Complex Subunit SAP18, 18kD Sin3-associated Polypeptide, 2HOR0202, Cell Growth-inhibiting Gene 38 Protein, Sin3-associated Polypeptide p18). Bone, Brain, Embryonic Tissue, Mouth, Muscle, Ovary, Salivary Gland, Testis tissues are correlated with this protein.