anti-Serotonin Receptor 3B antibody product blog
Tags: Antibody; Polyclonal Antibody; Serotonin Receptor 3B; anti-Serotonin Receptor 3B antibody;
The Serotonin Receptor 3B n/a (Catalog #MBS619568) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Serotonin Receptor 3B (HTR3B, 5-hydroxytryptamine (serotonin) receptor 3B, 5-HT-3B, 5-HT3B, 5-HT-3B, 5-hydroxytryptamine receptor 3B, HTR3B) reacts with Goat, Human and may cross-react with other species as described in the data sheet. MyBioSource\'s Serotonin Receptor 3B can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB).Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:16,000. Researchers should empirically determine the suitability of the Serotonin Receptor 3B n/a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Serotonin Receptor 3B (HTR3B, 5-hydroxytryptamine (serotonin) receptor 3B, 5-HT-3B, 5-HT3B, 5-HT-3B, 5-hydroxytryptamine receptor 3B, HTR3B) with the following immunoassay(s):
Chemiluminescence ((1ug/ml) staining of Human Cerebral Cortex lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)
Serotonin (5-hydroxytryptamine, 5-HT), originally discovered as a serum factor plays important roles in regulating diverse biological processes in central and peripheral nervous systems, cardiovascular systems, and gastrointestinal systems. The 5-HT3 receptors are distinguished from other 5-HT receptors by their structure and function. 5-HT3 receptors span the membrane only four times and are ligand-gated, cation-selective ion channels that mediate neuronal excitation and exocytotic release of neurotransmitters within the peripheral and central nervous systems. Functional studies done on isolated tissues have revealed heterogeneity of this receptor. The human 5-HT3R-As cDNA contains an open reading frame of 1434 base pairs predicting a 23-residue signal peptide and a mature receptor subunit of 455 amino acids. The human subunit exhibits 85% and 84% amino acid sequence identity to the mouse and rat receptors, respectively. Anti-5-HT3R polyclonal antibody shows immunoreactivity in the forebrain (olfactory regions, hippocampal formation and amygdala), sensory and motor nuclei of brainstem and spinal cord.
Immunogen: Peptide with sequence C-SNYLQTQDQTDQQE, from the internal region (near C-terminus) of human Serotonin Receptor 3B/Htr3b (NP_006019.1). In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing Serotonin Receptor 3B are readily searchable from our website. Different antibodies against the same target such as Serotonin Receptor 3B may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.