|The SIRP alpha sirpa (Catalog #MBS9411950) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SIRP alpha Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s SIRP alpha can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC). Researchers should empirically determine the suitability of the SIRP alpha sirpa for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The SIRP alpha sirpa product has the following accession number(s) (GI #18426911) (NCBI Accession #NP_542970). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the SIRP alpha Antibody with the following immunoassay(s):
Western Blot (WB) (Western blot analysis of SIRP alpha in THP-1 whole cell lysate with SIRP alpha antibody at 1:2000 dilution.)
Immunocytochemistry (ICC) (Immunocytochemistry of SIRP alpha in THP-1 cells with SIRP alpha antibody at 1 ug/mL.)
Protein tyrosine phosphatases (PTPases) SHP-1 and SHP-2 are critical regulators in the intracellular signaling pathways that result in cell responses such as mitosis, differentiation, migration, survival, transformation or death. SHP-2 is a signal transducer for several receptor tyrosine kinases and cytokine receptors. A novel SHP-2 associated glycoprotein was recently cloned from human, rat, mouse and cattle by several labs and was designated SIRPalpha, SHPS-1, MyD-1, BIT and p84. SIRPalpha is a new gene family containing at least fifteen members. SIRPalpha is a substrate of many activated tyrosine kinases such as insulin receptor, EGFR, PDGFR and src, and a specific docking protein for SHP-2. SIRPalpha has regulatory effects on cellular responses induced by serum, growth factors, insulin, oncogenes, growth hormones and cell adhesion and plays a general role in different physiological and pathological processes.
Immunogen Type: Peptide
Immunogen Description: Raised against a peptide corresponding to amino acids near the carboxy terminus of human SIRP alpha 1. The sequences of the immunogenic peptide differ from those of mouse, rat and bovine by one amino acid. Target Name: SIRP alpha. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing SIRP alpha are readily searchable from our website. Different antibodies against the same target such as SIRP alpha may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.