|The SIRPA sirpa (Catalog #MBS6004655) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SIRPA, CT (SIRPA, BIT, MFR, MYD1, SHPS1, SIRP, Tyrosine-protein phosphatase non-receptor type substrate 1, CD172, Inhibitory receptor SHPS-1, MyD-1, Signal-regulatory protein alpha-1, p84, CD172a) reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s SIRPA can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC).
Suitable for use in ELISA, Western Blot, Immunohistochemistry.
Dilution: ELISA: 1:20,000
Western Blot: 1:500-1:1000
Immunohistochemistry (Paraffin): 10ug/ml. Researchers should empirically determine the suitability of the SIRPA sirpa for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The SIRPA sirpa product has the following accession number(s) (GI #21619841) (NCBI Accession #AAH33092.1) (Uniprot Accession #P78324). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
SIRPA, CT (SIRPA, BIT, MFR, MYD1, SHPS1, SIRP, Tyrosine-protein phosphatase non-receptor type substrate 1, CD172, Inhibitory receptor SHPS-1, MyD-1, Signal-regulatory protein alpha-1, p84, CD172a)
Protein tyrosine phosphatases (PTPases) SHP-1 and SHP-2 are critical regulators in the intracellular signaling pathways that result in cell responses such as mitosis, differentiation, migration, survival, transformation or death. SHP-2 is a signal transducer for several receptor tyrosine kinases and cytokine receptors. A novel SHP-2 associated glycoprotein was recently cloned from human, rat, mouse and cattle by several labs and was designated SIRPa (1), SHPS-1 (2,3), MyD-1 (4), BIT (5,6) and p84 (7). SIRPa is a new gene family containing at least fifteen members. SIRPa is a substrate of many activated tyrosine kinases such as insulin receptor, EGFR, PDGFR and src, and a specific docking protein for SHP-2 (1,2,5,8). SIRPa has regulatory effects on cellular responses induced by serum, growth factors, insulin, oncogenes, growth hormones and cell adhesion and plays a general role in different physiological and pathological processes (1,2,5,8).
Immunogen: Synthetic peptide corresponding to human SIRPA at C-Terminal. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing SIRPA are readily searchable from our website. Different antibodies against the same target such as SIRPA may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene.