anti-SLC17A8 antibody product blog
Tags: Antibody; Polyclonal Antibody; VGLUT3; anti-Slc17a8 antibody; Slc17a8;
The SLC17A8 slc17a8 (Catalog #MBS630740) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The VGLUT3 (Vesicular Glutamate Transporter 3, Solute Carrier Family 17 Member 8, SLC17A8) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s VGLUT3 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB).Suitable for use in Western Blot and ELISA.
Dilution: Western Blot: 1-10ug/ml (Chemiluminescence)
ELISA: 1:100,000; 50-100ng of G4007-02A control peptide/well. Researchers should empirically determine the suitability of the SLC17A8 slc17a8 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The SLC17A8 slc17a8 product has the following accession number(s) (GI #223718438) (NCBI Accession #NP_001138760.1) (Uniprot Accession #Q8NDX2). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Vesicular glutamate transporter (VGLUT) is responsible for the active transport of L-glutamate in synaptic vesicles and thus plays an essential role in the glutamatergic chemical transmission in the central nervous system. VGLUT comprises three isoforms, VGLUT1, 2, and 3, and is a potential marker for the glutamatergic phenotype. Recent studies indicated that VGLUT is also expressed in non-neuronal cells, and localized with various organelles such as synaptic-like microvesicles in the pineal gland, and hormone- containing secretory granules in endocrine cells. L-Glutamate is stored in these organelles, secreted upon various forms of stimulation, and then acts as a paracrine-like modulator. Thus, VGLUTs highlight a novel framework of glutamatergic signaling and reveal its diverse modes of action. VGLUT3 expression is restricted to the brain, where it is predominantly located in synaptic vesicles. VGLUT3 shows strong sequence homology (~73%) to Differentiation-associated Na- dependent inorganic phosphate cotransporter. Mouse and rat respectively show 90 and 92% identity with the human VGLUT3 protein sequence.
Immunogen: Synthetic peptide corresponding to 18aa near the N-terminal, cytoplasmic domain of human VGLUT3 conjugated to KLH (Q8NDX2). Species Sequence Homology (100%): rat and mouse. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing SLC17A8 are readily searchable from our website. Different antibodies against the same target such as SLC17A8 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.