anti-SMAD3 antibody product blog
Tags: Antibody; anti-Smad3 antibody; Smad3; Mothers Against Decapentaplegic Homolog 3; Polyclonal Antibody;
The MADH3 smad3 (Catalog #MBS1489456) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit anti-human Mothers against decapentaplegic homolog 3 polyclonal Antibody, FITC reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s Mothers against decapentaplegic homolog 3 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA). Researchers should empirically determine the suitability of the MADH3 smad3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.The MADH3 smad3 product has the following accession number(s) (GI #223029440) (NCBI Accession #NP_001138574.1) (Uniprot Accession #P84022). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
Storage Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Conjugate: FITC. Immunogen: Recombinant human Mothers against decapentaplegic homolog 3 protein
Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-8332. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing MADH3 are readily searchable from our website. Different antibodies against the same target such as MADH3 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Breast Neoplasms, Cardiovascular Diseases, Disease Models, Animal, Fibrosis, Heart Diseases, Inflammation, Kidney Diseases, Liver Cirrhosis, Liver Diseases, Necrosis are some of the diseases may be linked to Rabbit anti-human Mothers against decapentaplegic homolog 3 polyclonal Antibody, FITC. Blood, Bone, Connective Tissue, Heart, Kidney, Liver, Lung, Muscle, Skin, Vascular tissues are correlated with this protein.