|The SNCA snca (Catalog #MBS7002897) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit anti-human Alpha-synuclein polyclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s Alpha-synuclein can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC).
Recommended dilution: WB:1:500-2000. Researchers should empirically determine the suitability of the SNCA snca for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The SNCA snca product has the following accession number(s) (GI #4507109) (NCBI Accession #NP_000336.1) (Uniprot Accession #P37840). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Rabbit anti-human Alpha-synuclein polyclonal Antibody with the following immunoassay(s):
Western Blot (WB) (All lanes: Alpha-synuclein antibody at 2ug/ml+293T whole cell lysate
Goat polyclonal to Rabbit IgG at 1/15000 dilution
Predicted band size: 15,12,14 kDa
Observed band size: 55 kDa,118 kDa
Immunohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded human melanoma using MBS7002897 at dilution 1:100)
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer s disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene.
Immunogen: Recombinant human Alpha-synuclein protein. Conjugation: Non-conjugated
Storage Buffer: Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing SNCA are readily searchable from our website. Different antibodies against the same target such as SNCA may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. SNCA also interacts with the following gene(s): APP, FYN, MAPT, PARK2, PARK7, SLC6A3, SNCAIP, UBC. The following patways have been known to be associated with this gene. Blood, Brain, Embryonic Tissue, Eye, Heart, Kidney, Liver, Nerve, Skin, Vascular tissues are correlated with this protein.