anti-SOX2 antibody product blog
Tags: Antibody; SOX2; Polyclonal Antibody; anti-SOX2 antibody; Sex determining region Y-box 2, SOX2;
The SOX2 n/a (Catalog #MBS355152) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-Sex determining region Y-box 2, SOX2 antibody reacts with Human, mouse and may cross-react with other species as described in the data sheet. MyBioSource\'s Sex determining region Y-box 2, SOX2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC).WB (1:1000); IHC-P (1:200); ICC (1:50-100). Researchers should empirically determine the suitability of the SOX2 n/a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
SRY (sex determining region Y)-box 2, also known as SOX2, is a transcription factor that is essential to maintain self-renewal of undifferentiated embryonic stem cells. SOX2 gene encodes a 317-amino acid protein,1 and lies in an intron of the SOX2OT (SOX2 overlapping transcript) gene with single-exon.2 SOX2 is expressed early in the embryonic stem cells of the blastocyst and later in the neural stem cells. It is a member of the SOX family of proteins that carry a DNA-binding high-mobility group (HMG) domain and additional domains that regulate embryonic development and cell fate determinations. Mutations in SOX2 can cause not only anophthalmia, but also aplasia of the optic nerve, chiasm and optic tract, as well as modest bilateral sensorineural hearing loss, and global developmental delay, underscoring the importance of SOX2 in early human eye and brain development.3 And the ectopic expression of SOX2 may be related to abnormal differentiation of colorectal cancer cells.^4.
Immunogen: A synthetic peptide (conjugated with KLH) corresponding to the region of SOX2. Storage Buffer: In TBS (pH7.4), 0.5% BSA, 40% Glycerol and 0.05% Sodium Azide
Storage Buffer: In TBS (pH7.4), 0.5% BSA, 40% Glycerol and 0.05% Sodium Azide. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing SOX2 are readily searchable from our website. Different antibodies against the same target such as SOX2 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.