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anti-SQSTM1 antibody product blog

Posted on 2015-10-14 20:11:53 by mybiosource_staff
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Tags: Antibody; Polyclonal Antibody; SQSTM1; anti-SQSTM1 antibody; p62 (Thr269, Ser272);
The SQSTM1 sqstm1 (Catalog #MBS502193) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-Phospho-Thr269/Ser272 p62 reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s p62 (Thr269, Ser272) can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB).
Quality Control: Western bots performed on each lot.
WB: 1:1000. Researchers should empirically determine the suitability of the SQSTM1 sqstm1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.

The SQSTM1 sqstm1 product has the following accession number(s) (GI #214830438) (NCBI Accession #NP_001135770.1) (Uniprot Accession #Q13501). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:

Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Anti-Phospho-Thr269/Ser272 p62 with the following immunoassay(s):
Testing Data
Testing Data SQSTM1.

Affinity purified rabbit polyclonal antibody.

Antigen: Phosphopeptide corresponding to amino acid residues surrounding the phospho-Thr269/Ser272 of human p62.
Immunogen Information: Synthetic phospho-peptide corresponding to amino acid residues surrounding Thr269/Ser272 conjugated to KLH
Immunogen Species: Human. Reactivity Assumed Based on 100% Sequence Homology: Non-human primates
Species Reactivity Note: The antibody has been directly tested for reactivity in Western blots with human tissue. It is anticipated that the antibody will also react with non-human primates based on the fact that these species have 100% homology with the amino acid sequence used as antigen.
Biological Significance: The protein scaffold and signaling regulator p62 (also known as sequestosome1 (SQSTM1)) is important in critical cellular functions, including bone homeostasis, obesity, and cancer, because of its interactions with various signaling intermediaries. p62 is overexpressed in many human cancers and is induced during cell transformation. cdk1 phosphorylates p62 in vitro and in vivo at T269 and S272, which is necessary for the maintenance of appropriate cyclin B1 levels and the levels of cdk1 activity necessary to allow cells to properly enter and exit mitosis (Moscat et al., 2011). The lack of cdk1-mediated phosphorylation of p62 leads to a faster exit from mitosis, translating into enhanced ell proliferation and tumorigenesis in response to Ras-induced transformation (Moscat et al., 2011). In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing SQSTM1 are readily searchable from our website. Different antibodies against the same target such as SQSTM1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.
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