|The SREBF1 srebf1 (Catalog #MBS626884) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SREBF1, ID (Processed Sterol Regulatory Element-binding Protein 1, Class D Basic Helix-loop-helix Protein 1, bHLHd1, Sterol Regulatory Element-binding Transcription Factor 1, Sterol Regulatory Element-binding Protein 1, SREBP-1, BHLHD1) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s SREBF1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB).
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500. Researchers should empirically determine the suitability of the SREBF1 srebf1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The SREBF1 srebf1 product has the following accession number(s) (GI #52630419) (NCBI Accession #NP_001005291.1) (Uniprot Accession #P36956). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
SREBF1 is a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family.
Immunogen: Synthetic peptide selected from the Center region of human SREBF1 (KLH). In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing SREBF1 are readily searchable from our website. Different antibodies against the same target such as SREBF1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. Blood, Brain, Connective Tissue, Kidney, Liver, Muscle, Ovary, Pancreas, Thyroid, Vascular tissues are correlated with this protein. Arteriosclerosis, Diabetes Mellitus, Type 2, Dyslipidemias, Fatty Liver, Hyperinsulinism, Hyperlipidemias, Insulin Resistance, Liver Diseases, Neoplasms, Obesity are some of the diseases may be linked to SREBF1, ID (Processed Sterol Regulatory Element-binding Protein 1, Class D Basic Helix-loop-helix Protein 1, bHLHd1, Sterol Regulatory Element-binding Transcription Factor 1, Sterol Regulatory Element-binding Protein 1, SREBP-1, BHLHD1).