|The STAT3 stat3 (Catalog #MBS175452) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-STAT3 antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s STAT3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Immunocytochemistry (ICC). Researchers should empirically determine the suitability of the STAT3 stat3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The STAT3 stat3 product has the following accession number(s) (GI #48429227) (NCBI Accession #P40763.2) (Uniprot Accession #P40763). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Anti-STAT3 antibody with the following immunoassay(s):
Western Blot (WB) (Anti-STAT3 antibody, MBS175452, Western blotting
WB: Rat Brain Tissue Lysate )
Immunohistochemistry (IHC) (Anti-STAT3 antibody, MBS175452, IHC(P)
IHC(P): Human Mammary Cancer Tissue )
Description: Rabbit IgG polyclonal antibody for Signal transducer and activator of transcription 3(STAT3) detection. Tested with WB, IHC-P, ICC in Human, Mouse, Rat.
Background: The transcription factor, signal transducer and activator of transcription-3(STAT-3) is the most pleiotropic member of the signal transducer and activator of transcription(STAT) family of transcription factors and mediates pivotal responses for the cytokine family. The mouse STAT3 gene contains 24 exons and spans 30 kb. The translation initiation codon is in exon 2, and the stop codon is in exon 24. STAT3 is mapped to 17q21, it contributes to various physiological processes. Hepatic STAT-3 signaling is thus essential for normal glucose homeostasis and may provide new therapeutic targets for diabetes mellitus.
Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human STAT3 (686-698aa YCRPESQEHPEAD), identical to the related rat and mouse sequences. Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing STAT3 are readily searchable from our website. Different antibodies against the same target such as STAT3 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.