anti-SUZ12 antibody product blog
Tags: Antibody; Polyclonal Antibody; anti-SUZ12 antibody; SUZ12;
The SUZ12 suz12 (Catalog #MBS153413) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SUZ12 Antibody reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s SUZ12 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF).SUZ12 antibody can be used for detection of SUZ12 by Western blot at 1 - 2 mug/ml. Antibody can also be used for Immunohistochemistry starting at 5 mug/mL. For immunofluorescence start at 20 mug/mL. Researchers should empirically determine the suitability of the SUZ12 suz12 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The SUZ12 suz12 product has the following accession number(s) (GI #197333809) (NCBI Accession #NP_056170) (Uniprot Accession #Q15022). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the SUZ12 Antibody with the following immunoassay(s):
Western Blot (WB) (Western blot analysis of SUZ12 in human liver tissue lysate with SUZ12 antibody at 1 μg/ml.)
Immunohistochemistry (IHC) (Immunohistochemistry of SUZ12 in human lung tissue with SUZ12 antibody at 5 μg/mL.)
Immunofluorescence (IF) (Immunofluorescence of SUZ12 in human lung tissue with SUZ12 antibody at 20 μg/mL.)
The Polycomb group (PcG) genes contribute to the maintenance of cell identity, cell cycle regulation and oncogenesis (1). SUZ12 (suppressor of zeste 12) is a 90 - 95 kDa member of the polycomb group of transcriptional regulators (2). It is part of a transcription repression complex termed PRC2 (Polycomb repressive complex 2) that methylates histones in the nucleus, resulting in homeotic (pattern-inducing) gene silencing. It contains one C2H2-type zinc finger region and a C-terminal VEFS-box (3,4). SUZ12 is overexpressed in breast and colon cancer. SUZ12 may be a cause of endometrial stromal tumors (5).
Conjugate: Unconjugated
Immunogen: SUZ12 antibody was raised against a 19 amino acid peptide near the center of human SUZ12.
Buffer: SUZ12 antibody is supplied in PBS containing 0.02% sodium azide. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing SUZ12 are readily searchable from our website. Different antibodies against the same target such as SUZ12 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.