anti-tau antibody product blog
Tags: Antibody; TAU; Polyclonal Antibody; anti-TAU antibody;
The tau n/a (Catalog #MBS627992) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Tau, phosphorylated (Ser199) (Tau Protein, Microtubule-associated Protein, MAP) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s Tau can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB).Suitable for use in Western Blot.
Dilution: Western Blot: 1:1000
Optimal dilution to be determined by the researcher. Researchers should empirically determine the suitability of the tau n/a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The tau n/a product has the following accession number(s) (GI #21357661) (NCBI Accession #NP_651575.1). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Tau is a neuronal microtubule-associated protein found predominantly on axons that functions to promote tubulin polymerization and stabilize microtubules. Tau, in its hyperphosphorylated form, is the major component of paired helical filaments (PHF), the building block of neurofibrillary lesions in Alzheimer\'s disease (AD) brain. Hyperphosphorylated tau is also found in neurofibrillary lesions in a range of other central nervous system disorders. Hyperphosphorylation impairs the microtubule binding function of tau, resulting in the destabilization of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Numerous serine/threonine kinases including GSK-3, protein kinase A (PKA), cyclin-dependent kinase 5 (cdk5) and casein kinase II, phosphorylate tau. Phosphorylation of serine 199 is catalyzed by GSK-3 in vitro and has been linked to frontotemporal dementia.
Immunogen: Synthetic phosphopeptide corresponding to human tau that contains serine 199. Species sequence homology: mouse and rat. Positive Control: Recombinant human Tau treated with GSK-3 ; African green monkey kidney (CV-1) cells, stably expressing human four repeat tau and SV40 small T antigen to induce specific inhibition of PP2A. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing tau are readily searchable from our website. Different antibodies against the same target such as tau may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Bone, Brain, Connective Tissue, Ear, Embryonic Tissue, Heart, Kidney, Muscle, Umbilical Cord, Vascular tissues are correlated with this protein.