|The TBCE tbce (Catalog #MBS6001686) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The TBCE (Tubulin-specific Chaperone E, Tubulin-folding Cofactor E) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s TBCE can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB).
Suitable for use in Western Blot. Researchers should empirically determine the suitability of the TBCE tbce for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The TBCE tbce product has the following accession number(s) (GI #118442828) (NCBI Accession #NP_001072983.1) (Uniprot Accession #Q15813). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful. The amino acid sequence is listed below:
MSDTLTADVI GRRVEVNGEH ATVRFAGVVP PVAGPWLGVE WDNPERGKHD GSHEGTVYFK CRHPTGGSFI RPNKVNFGTD FLTAIKNRYV LEDGPEEDRK EQIVTIGNKP VETIGFDSIM KQQSQLSKLQ EVSLRNCAVS CAGEKGGVAE ACPNIRKVDL SKNLLSSWDE VIHIADQLRH LEVLNVSENK LKFPSGSVLT GTLSVLKVLV LNQTGITWAE VLRCVAGCPG LEELYLESNN IFISERPTDV LQTVKLLDLS SNQLIDENQL YLIAHLPRLE QLILSDTGIS SLHFPDAGIG CKTSMFPSLK YLVVNDNQIS QWSFFNELEK LPSLRALSCL RNPLTKEDKE AETARLLIIA SIGQLKTLNK CEILPEERRR AELDYRKAFG NEWKQAGGHK DPEKNRLSEE FLTAHPRYQF LCLKYGAPED WELKTQQPLM LKNQLLTLKI KYPHQLDQKV LEKQLPGSMT IQKVKGLLSR LLKVPVSDLL LSYESPKKPG REIELENDLK SLQFYSVENG DCLLVRW.
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Cofactor E is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors An and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state.
Immunogen: Full length human TBCE, aa1-527 (AAH08654). In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing TBCE are readily searchable from our website. Different antibodies against the same target such as TBCE may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Blood, Bone, Brain, Embryonic Tissue, Eye, Muscle, Ovary, Pharynx, Stomach, Testis tissues are correlated with this protein. The following patways have been known to be associated with this gene. TBCE also interacts with the following gene(s): TBCA, TBCB, TBCC, TBCD. Bacterial Infections, Brain Diseases, Craniofacial Abnormalities, Facies, Hypoparathyroidism-retardation-dysmorphism syndrome, Kenny Caffey syndrome, Kenny-Caffey syndrome, Type 1, Neoplasms, Neurotoxicity Syndromes, Osteosclerosis are some of the diseases may be linked to TBCE (Tubulin-specific Chaperone E, Tubulin-folding Cofactor E).