anti-TEK antibody product blog
Tags: Antibody; Polyclonal Antibody; TIE2; anti-TEK antibody; TEK;
The TEK tek (Catalog #MBS615356) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Tie2 (Tunica Internal Endothelial Cell Kinase, Angiopoietin1 Receptor, p140 Tek, Tyrosine Protein Kinase Receptor) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s Tie2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA).Dilution: ELISA: 1:10,000-1:100,000; using 50-100ng of control peptide/well. Researchers should empirically determine the suitability of the TEK tek for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The TEK tek product has the following accession number(s) (GI #112180440) (NCBI Accession #AAH35514.2) (Uniprot Accession #Q02763). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Embryonic vascular system undergoes a series of complex, highly regulated series of events involving differentiation, migration and association of primitive endothelial cells. This process is termed vasculogenesis. A further remodeling of the primitive vascular system forms the mature cardiovascular system. This process is known as angiogenesis (sprouting of new capillary vessels from pre-existing vasculature). A family of receptor tyrosine kinases TIE1 and TIE 2 or Tek has been identified in vascular endothelium and hematopoietic cells. Mice lacking TIE 1 or TIE 2 are lethal. Ties may represent the earliest endothelial cell lineage marker and may regulate the endothelial cell proliferation, differentiation, and proper patterning during vasculogenesis. TIEs appear to be acting downstream of the VEGFRs. Tie-2 (human 1124 AA; mouse 1122 aa) is a type 1 membrane receptor protein specifically expressed in developing vascular endothelial cells and their progenitors, angioblasts. It is also found in placenta and lung, with lower levels in umbilical vein endothelial cells, brain and kidney. Tie-2 extracellular portion (25-279 aa) contains 3 fibronectin type III-like and 2-Ig-like C2-type, and 3-EGF-like domains.
Immunogen: Synthetic peptide corresponding to 18aa, ~N-terminal, extracellular of human Tie2. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing TEK are readily searchable from our website. Different antibodies against the same target such as TEK may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. TEK also interacts with the following gene(s): ANGPT1, ANGPT2, ANGPT4, DOK2, GRB14, GRB2, GRB7, PTPN11, SHC1.