anti-TGM2 antibody product blog
Tags: Antibody; Polyclonal Antibody; TGM2; anti-TGM2 antibody; Transglutaminase 2;
The TGM2 tgm2 (Catalog #MBS176178) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-Transglutaminase 2 antibody reacts with Human, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s Transglutaminase 2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Immunocytochemistry (ICC). Researchers should empirically determine the suitability of the TGM2 tgm2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.The TGM2 tgm2 product has the following accession number(s) (GI #20141877) (NCBI Accession #P21980.2) (Uniprot Accession #P21980). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Anti-Transglutaminase 2 antibody with the following immunoassay(s):
Western Blot (WB) (Anti-TGM2 antibody, MBS176178, Western blotting
Lane 1: JURKAT Cell Lysate
Lane 2: HELA Cell Lysate
)
Immunohistochemistry (IHC) (Anti-TGM2 antibody, MBS176178, IHC(P)
IHC(P): Human Lung Cancer Tissue )
Description: Rabbit IgG polyclonal antibody for Protein-glutamine gamma-glutamyltransferase 2(TGM2) detection. Tested with WB, IHC-P, ICC in Human, Rat.
Background: Tissue transglutaminase, also called TGC, is a 78-kDa, calcium dependent enzyme of the protein-glutamine gamma-glutamyltransferases family. By fluorescence in situ hybridization(FISH), this gene is mapped in 20q11.23. Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease.
Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human Transglutaminase 2 (399-418aa ADVVDWIQQDDGSVHKSINR), different from the related mouse sequence by three amino acids, and from the related rat sequence by four amino acids. Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing TGM2 are readily searchable from our website. Different antibodies against the same target such as TGM2 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.