|The TH n/a (Catalog #MBS625642) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Tyrosine Hydroxylase, phosphorylated (Ser40) (TH, TYH, Tyrosine 3 Hydroxylase, Tyrosine 3 Monooxygenase) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s Tyrosine Hydroxylase can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF).
Suitable for use in Immunofluorescence, Flow Cytometry, ELISA, Western Blot and Immunocytochemistry.,, Recommended Dilution:, Western Blot: 1:1000, Immunocytochemistry (IF): 1:200, Optimal dilutions to be determined by the researcher. Researchers should empirically determine the suitability of the TH n/a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The TH n/a product has the following accession number(s) (GI #986909) (Uniprot Accession #O43816). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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Tyrosine hydroxylase catalyzes the rate limiting step in the synthesis of dopamine and other catecholamines. The enzyme\'s activity is regulated at the levels of transcription, translation and post-translational modification. Tyrosine hydroxylase exists in several different isoforms ranging from 50kD to about 62kD in human. The N-terminal regulatory domain contains three phospho-serine sites: Ser19, Ser31 and Ser40. Phosphorylation at Ser40 by PKA positively.
Immunogen: Synthetic phosphopeptide (KLH coupled) around Ser40 of human tyrosine hydroxylase. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing TH are readily searchable from our website. Different antibodies against the same target such as TH may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Brain Diseases, Cardiovascular Diseases, Gastrointestinal Diseases, Heart Diseases, Kidney Diseases, Mental Disorders, Myocardial Ischemia, Neoplasms, Nervous System Diseases, Pain are some of the diseases may be linked to Tyrosine Hydroxylase, phosphorylated (Ser40) (TH, TYH, Tyrosine 3 Hydroxylase, Tyrosine 3 Monooxygenase). Adrenal Gland, Brain, Embryonic Tissue, Eye, Mouth, Nerve, Pancreas, Placenta, Uncharacterized Tissue tissues are correlated with this protein. The following patways have been known to be associated with this gene. TH also interacts with the following gene(s): CAMK2G, MAPK1, MAPK3, MAPKAPK2, SNCA, YWHAB, YWHAZ.