|The TIE2 tek (Catalog #MBS9406636) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TIE2 (Phospho-Tyr992) Antibody reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s TIE2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB).
Western blotting: 1:500~1:1000. Researchers should empirically determine the suitability of the TIE2 tek for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The TIE2 tek product has the following accession number(s) (GI #88758596) (NCBI Accession #NP_000450.2) (Uniprot Accession #Q02763). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the TIE2 (Phospho-Tyr992) Antibody with the following immunoassay(s):
Western Blot (WB) (Western blot analysis of extracts from HepG2 using TIE2 (Phospho-Tyr992) Antibody.The lane on the right is treated with the antigen-specific peptide.)
The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses an unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase.Schooley K.A., Baum P.R. Oncogene 8:663-670(1993)Dunham I. Nature 429:369-374(2004)Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Immunogen Type: Peptide-KLH
Immunogen Description: Peptide sequence around phosphorylation site of tyrosine 992 (E-V-Y(p)-V-K) derived from Human TIE2. Modification: Phospho-Tyr992
Target Name: TIE2. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing TIE2 are readily searchable from our website. Different antibodies against the same target such as TIE2 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. TIE2 also interacts with the following gene(s): ANGPT1, ANGPT2, ANGPT4, DOK2, GRB14, GRB2, PTPN11, SHC1. The following patways have been known to be associated with this gene. Bladder, Brain, Embryonic Tissue, Kidney, Lung, Mouth, Muscle, Placenta, Uterus, Vascular tissues are correlated with this protein.