|The Timeless timeless (Catalog #MBS540125) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Timeless Antibody Affinity Purified reacts with Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s Timeless can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB).
Dot Blot: 1:10,000
Western Blot: 1:500. Researchers should empirically determine the suitability of the Timeless timeless for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The Timeless timeless product has the following accession number(s) (GI #6755789) (NCBI Accession #NP_035719.1) (Uniprot Accession #Q9R1X4). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Timeless Antibody Affinity Purified with the following immunoassay(s):
Western Blot (WB)
Affinity Purified Protein timeless homolog isoform 2 Antibody
Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication and in the regulation of the circadian clock. Involved in the determination of period length and in the DNA damage-dependent phase advancing of the circadian clock.
Immunogen: Synthetic peptide taken within amino acid region 1170-1200 on Timeless protein.
Expression: Predominantly and robustly expressed in proliferative organs (spleen, thymus, intestine and testis) compared to those more differentiated such as kidney and liver (at protein level). Expressed in all tissues examined including brain, heart, lung, liver, s. Molecular Function: Developmental protein, protein heterodimerization activity, protein homodimerization activity
Structure: Homodimer or homomultimer. Component of the circadian core oscillator, which includes the CRY proteins, CLOCK or NPAS2, ARTNL/BMAL1 or ARTNL2/BMAL2, CSKN1D and/or CSNK1E, TIMELESS, and the PER proteins. Interacts directly with PER1, PER2 and PER3; the int
Subcellular Location: Nucleus. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing Timeless are readily searchable from our website. Different antibodies against the same target such as Timeless may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. Adenocarcinoma, Breast Neoplasms, Carcinoma, Carcinoma, Hepatocellular, Depressive Disorder, Hypertension, Inflammation, Liver Diseases, Liver Neoplasms, Neoplasm Metastasis are some of the diseases may be linked to Timeless Antibody Affinity Purified.