|The TLR3 tlr3 (Catalog #MBS7049292) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TLR3 Antibody reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s TLR3 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC), Immunofluorescence (IF).
IHC: 1: 20-1: 200
IF: 1: 50-1: 200. Researchers should empirically determine the suitability of the TLR3 tlr3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The TLR3 tlr3 product has the following accession number(s) (GI #4507531) (NCBI Accession #NP_003256.1) (Uniprot Accession #O15455). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the TLR3 Antibody with the following immunoassay(s):
Immunohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded human pancreatic cancer using MBS7049292 at dilution of 1:100)
Immunohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded human kidney tissue using MBS7049292 at dilution of 1:100)
Immunohistochemistry (IHC) (Immunofluorescent analysis of Hela cells using MBS7049292 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L))
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response.
Immunogen: Recombinant human Toll-like receptor 3 protein (135-297AA). Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-23323 / sc-8691 / sc-12509 / sc-16238 / sc-8692 / sc-28999 / sc-10740. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing TLR3 are readily searchable from our website. Different antibodies against the same target such as TLR3 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. Bone, Brain, Eye, Intestine, Kidney, Liver, Lung, Muscle, Skin, Spleen tissues are correlated with this protein. TLR3 also interacts with the following gene(s): DDX58, MYD88, NFKB1, RIPK1, TAB2, TICAM1, TRAF6, UNC93B1. Adenocarcinoma, Carcinoma, Hepatocellular, Encephalitis, Herpes Simplex, Fibrosis, Heart Diseases, Inflammation, Kidney Diseases, Lung Diseases, Necrosis, Vascular Diseases are some of the diseases may be linked to TLR3 Antibody.