anti-TLR4 antibody product blog
Tags: Antibody; TLR4; Polyclonal Antibody; anti-TLR4 antibody;
The TLR4 tlr4 (Catalog #MBS247240) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit Polyclonal to Human TLR4 reacts with Bovine, Chimpanzee, Gorilla, Horse, Human, Macaque and may cross-react with other species as described in the data sheet. MyBioSource\'s TLR4 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC - Paraffin), Western Blot (WB).IHC-P (5 ug/ml), WB (0.1 - 0.5 ug/ml). Researchers should empirically determine the suitability of the TLR4 tlr4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The TLR4 tlr4 product has the following accession number(s) (GI #4507533) (NCBI Accession #NP_003257.1) (Uniprot Accession #O00206). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Rabbit Polyclonal to Human TLR4 with the following immunoassay(s):
Immunohistochemistry (IHC) (Anti-TLR4 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 5 ug/ml.)
Western Blot (WB) (Western blot of TLR4 in human intestine lysate in the 1) absence and 2) presence of immunizing peptide using TLR4 antibody at 0.1 ug/ml. Goat anti-rabbit Ig HRP secondary antibody, and PicoTect ECL substrate solution, were used for this test.)
Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors such as Protein Kinase C (PKC) alpha/beta and NF-kB. Studies with TLR4-deficient mice indicate that the main ligand for TLR is lipopolysaccharide.
Target Species: Human
Immunogen Description: A portion of amino acids 650-700 of human TLR4 was used as the immunogen for this antibody. Immunogen Type: Synthetic peptide
Immunogen: TLR4 antibody was raised against a portion of amino acids 650-700 of human TLR4 was used as the immunogen for this antibody.
Antigen Modification: aa650-700. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing TLR4 are readily searchable from our website. Different antibodies against the same target such as TLR4 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.