anti-TNF antibody product blog
Tags: Antibody; TNF; Polyclonal Antibody; anti-TNF antibody; TNF Receptor Type I;
The TNF tradd (Catalog #MBS535846) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TNF Receptor Type I antibody reacts with Human TNF receptor and may cross-react with other species as described in the data sheet. MyBioSource\'s TNF Receptor Type I can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Inhibition, Western Blot (WB).ELISA: 0.5-2 ug/ml
Inhibition: 0.9-1.1 ug/ml
WB: 0.1-0.2 ug/ml. Researchers should empirically determine the suitability of the TNF tradd for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The TNF tradd product has the following accession number(s) (GI #13378137) (NCBI Accession #NP_003780.1). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Affinity purified Rabbit polyclonal TNF Receptor Type I antibody.
Biological Significance: TNFR1 belongs to the TNFR superfamily of transmembrane proteins, and is expressed in most cell types. Binding of either TNF-alpha or TNF-beta to TNFR1 initiates a signal transduction pathway that results in the activation of the transduction factor NF kb, whose target genes are involved in the regulation of inflammatory responses, and, in certain cells induce apoptosis. Soluble TNF Receptor I (sTNFR1) is capable of inhibiting TNF-alpha and TNF-beta activities by acting as a decoy receptor that serves as a sink for the TNF ligands. Immunogen: TNF receptor type I antibody was raised in rabbit using highly pure recombinant human sTNF-receptor as the immunogen. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing TNF are readily searchable from our website. Different antibodies against the same target such as TNF may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. Breast Neoplasms, Carcinoma, Hepatocellular, Cell Transformation, Neoplastic, Inflammation, Liver Diseases, Liver Neoplasms, Lung Diseases, Necrosis, Neoplasm Metastasis, Neoplasms, Experimental are some of the diseases may be linked to TNF Receptor Type I antibody. TNF also interacts with the following gene(s): CASP8, FADD, FAS, RIPK1, TNFRSF10B, TNFRSF1A, TNFRSF25, TRAF1, TRAF2, TRAF3. Bone, Bone Marrow, Brain, Heart, Kidney, Liver, Lung, Prostate, Skin, Spleen tissues are correlated with this protein.