|The TREX1 trex1 (Catalog #MBS2536405) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TREX1 Polyclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s TREX1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF).
WB: 1:500-1:2000, IHC: 1:50-1:200, IF: 1:50-1:200. Researchers should empirically determine the suitability of the TREX1 trex1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The TREX1 trex1 product has the following accession number(s) (GI #404434375) (NCBI Accession #NP_009179.2). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the TREX1 Polyclonal Antibody with the following immunoassay(s):
Western Blot (WB) (Western blot analysis of extracts of various cell lines, using TREX1 antibody.)
Immunofluorescence (IF) (Immunofluorescence analysis of A549 cell using TREX1 antibody. Blue: DAPI for nuclear staining.)
Background/Introduction: This gene encodes a nuclear protein with 3\' exonuclease activity. The encoded protein may play a role in DNA repair and serve as a proofreading function for DNA polymerase. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, Cree encephalitis, and other diseases of the immune system. Alternative splicing results in multiple transcript variants.
In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing TREX1 are readily searchable from our website. Different antibodies against the same target such as TREX1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. Aicardi-Goutieres syndrome, Brain Diseases, Chilblain lupus 1, Congenital Abnormalities, Disease Models, Animal, Inflammation, Lupus Erythematosus, Systemic, Necrosis, Nervous System Diseases, Vasculopathy, Retinal, With Cerebral Leukodystrophy are some of the diseases may be linked to TREX1 Polyclonal Antibody. Blood, Bone Marrow, Brain, Connective Tissue, Eye, Ganglia, Kidney, Mammary Gland, Skin, Spleen tissues are correlated with this protein. TREX1 also interacts with the following gene(s): ATM, ATR, IRF3, TBK1.