anti-TSC1 antibody product blog
Tags: Antibody; Polyclonal Antibody; Hamartin; anti-TSC1 antibody; TSC1;
The TSC1 tsc1 (Catalog #MBS629035) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Hamartin, phosphorylated (Ser505) (TSC1, Tuberous Sclerosis 1 Protein, KIAA0243, TSC) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s Hamartin can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Gel Shift Assay (GS/EMSA).Suitable for use in ELISA and Dot Blot.
Dilution: ELISA: 1:1000
Dot Blot: 1:500. Researchers should empirically determine the suitability of the TSC1 tsc1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The TSC1 tsc1 product has the following accession number(s) (GI #241666464) (NCBI Accession #NP_001155899.1) (Uniprot Accession #Q0VAM5). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the Hamartin, phosphorylated (Ser505) (TSC1, Tuberous Sclerosis 1 Protein, KIAA0243, TSC) with the following immunoassay(s):
Dot Blot (DB) (Dot blot analysis of anti-TSC1-pS505 Phospho-specific Pab (RB13337) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5ug per ml.)
TSC1 is implicated as a tumor suppressor, and may have a function in vesicular transport. Interaction between TSC1 and TSC2 may facilitate vesicular docking Defects in TSC1 are the cause of tuberous sclerosis complex (TSC). The molecular basis of TSC is a functional impairement of the hamartin-tuberin complex. TSC is an autosomal dominant multi-system disorder that affects especially the brain, kidneys, heart, and skin. Defects in TSC1 may be a cause of focal cortical dysplasia of Taylor balloon cell type (FCDBC). FCDBC is a subtype of cortical displasias linked to chronic intractable epilepsy. Cortical dysplasias display a broad spectrum of structural changes, which appear to result from changes in proliferation, migration, differentiation, and apoptosis of neuronal precursors and neurons during cortical development.
Immunogen: Synthetic phosphopeptide corresponding to amino acid residues surrounding Ser505 of human TSC1 (KLH). In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing TSC1 are readily searchable from our website. Different antibodies against the same target such as TSC1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.