anti-UNG antibody product blog
Tags: Antibody; Polyclonal Antibody; anti-UNG antibody; UNG; UNG1;
The UNG ung (Catalog #MBS151379) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The UNG1 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s UNG1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF).UNG1 antibody can be used for the detection of UNG1 by Western blot at 0.5 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 2 mug/mL. For immunofluorescence start at 20 mug/mL. Researchers should empirically determine the suitability of the UNG ung for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The UNG ung product has the following accession number(s) (GI #6224979) (NCBI Accession #NP_003353) (Uniprot Accession #P13051). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the UNG1 Antibody with the following immunoassay(s):
Western Blot (WB) (Western blot analysis of UNG1 in C2C12 cell lysate with UNG1 antibody at (A) 0.5, (B) 1 and (C) 2 μg/mL.)
Immunohistochemistry (IHC) (Immunohistochemistry of UNG1 in human heart tissue with UNG1 antibody at 2 μg/mL.)
Immunofluorescence (IF) (Immunofluorescence of UNG1 in Human Heart cells with UNG1 antibody at 20 μg/mL.)
UNG1 Antibody: The human uracil-DNA glycosylase (UNG) gene encodes both mitochondrial (UNG1) and nuclear (UNG2) forms through differentially regulated promotes and alternative splicing. While UNG2 is the major enzyme in the base excision repair pathway that removes uracil residues from nuclear DNA that arise through either misincorporation during replication or cytosine deamination, inhibition of UNG1 by uracil glycosylase inhibitor did not lead to increased levels of spontaneous or induced mitochondrial DNA mutations. However, decreased levels of UNG activity and increased oxidative damage to mitochondrial DNA were seen in older mice, suggesting that mitochondrial DNA repair mechanisms may be involved in various neurodegenerative disorders in an age-dependent manner. This UNG1 antibody will not cross-react with UNG2.
Conjugate: Unconjugated
Immunogen: UNG1 antibody was raised against a 14 amino acid synthetic peptide from near the carboxy terminus of human UNG1.
Buffer: UNG1 Antibody is supplied in PBS containing 0.02% sodium azide. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing UNG are readily searchable from our website. Different antibodies against the same target such as UNG may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.