anti-UTS2R antibody product blog
Tags: Antibody; Polyclonal Antibody; UTS2R; anti-UTS2R antibody; GPR14;
The UTS2R uts2r (Catalog #MBS619121) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The GPR14 (UII Receptor) reacts with Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s GPR14 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB).Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:10,000-1:100,000 using 50-100ng control peptide/well.
Western Blot: 1:1000- 1:5000. Researchers should empirically determine the suitability of the UTS2R uts2r for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The UTS2R uts2r product has the following accession number(s) (GI #5902616) (Uniprot Accession #Q9UKP6). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Urotensins are neuropeptide secreted from the urophysis in the caudal neurosecretory system of the fishes. Two bioactive Urotensins, U1 and UII have been cloned from various species including mammals. UI is 41 aa peptide, which showed prolonged hypotensive effects in mammals. It is structurally similar to mammalian corticotropin-releasing factor. UII is a vasoactive \'somatostatin-like" 12-aa cyclic peptide with similarity to somatostatin-14. Human UII is composed of only 11 aa residues, while fish and frog UII possess 12 and 13 aa, respectively. The cyclic region of the UII, which is responsible for the biological activity of the peptide, has been fully conserved from fish to human. UII expression has been observed predominantly in the spinal cord. Recently, an orphan human G-protein coupled receptor homologous to rat GPR14 has been identified as the receptor for UII (2). GPR14 is expressed predominantly in cardiovascular tissue. Human UII effectively stimulated total peripheral resistance in anesthetized non-human primates, a response associated with profound cardiac contractile dysfunction. GPR14 (rat 386 aa and human 389 aa, ~75% homology) contains 7 transmembrane domains. It is most closely related to somatostatin receptor4. GPR14 is mostly expressed in the heart and pancreas, while low expression was detected in the brain.
Immunogen: An 18-aa peptide near the C-terminus of rat GPR14 (2) was synthesized, coupled to KLH (carrier protein). In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing UTS2R are readily searchable from our website. Different antibodies against the same target such as UTS2R may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.