|The WAS was (Catalog #MBS9203380) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The WAS Antibody (Center) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s WAS can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA).
WB~~1:1000. Researchers should empirically determine the suitability of the WAS was for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The WAS was product has the following accession number(s) (GI #4507909) (NCBI Accession #NP_000368.1) (Uniprot Accession #P42768). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given antibody. We\'ve tested the WAS Antibody (Center) with the following immunoassay(s):
Western Blot (WB) (WAS Antibody (Center) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the WAS antibody detected the WAS protein (arrow).)
The Wiskott-Aldrich syndrome (WAS) family of proteins
share similar domain structure, and are involved in transduction of
signals from receptors on the cell surface to the actin
cytoskeleton. The presence of a number of different motifs
suggests that they are regulated by a number of different stimuli,
and interact with multiple proteins. Recent studies have
demonstrated that these proteins, directly or indirectly, associate
with the small GTPase, Cdc42, known to regulate formation of actin
filaments, and the cytoskeletal organizing complex, Arp2/3.
Wiskott-Aldrich syndrome is a rare, inherited, X-linked, recessive
disease characterized by immune dysregulation and
microthrombocytopenia, and is caused by mutations in the WAS gene.
The WAS gene product is a cytoplasmic protein, expressed
exclusively in hematopoietic cells, which show signalling and
cytoskeletal abnormalities in WAS patients. A transcript variant
arising as a result of alternative promoter usage, and containing a
different 5\' UTR sequence, has been described, however, its
full-length nature is not known.
Antigen Type: Synthetic Peptide. Antigen Source: HUMAN. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing WAS are readily searchable from our website. Different antibodies against the same target such as WAS may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene.