anti-Effector Cell Protease Receptor-1 antibody product blogThe Effector Cell Protease Receptor-1 n/a (Catalog #MBS613097) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Effector Cell Protease Receptor-1 (EPR-1) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s Effector Cell Protease Receptor-1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB).
Suitable for use in ELISA and Western Blot.
Dilution: Western Blot: 1-10ug/ml using ECL. Detects a ~62kD protein in detergent solubilized extracts of Jurkat and monocytic THP-1 cells.
ELISA: 1:10,000-1:100,000 using 50-100ng of control peptide/well. Researchers should empirically determine the suitability of the Effector Cell Protease Receptor-1 n/a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The Effector Cell Protease Receptor-1 n/a product has the following accession number(s) (GI #601850). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
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The inhibitors of apoptosis proteins (IAPs) are a widely expressed gene family of apoptotic inhibitors. Recently, a new human gene encoding a structurally and unique IAP designated Survivin has been identified. Survivin (human 142 aa, ~16.5kD) is highly expressed in less-differentiated embryonic cells or rapidly dividing tumor cell but not in fully differentiated adult tissues. Interestingly, Survivin coding strand has significant sequence homology with Effector cell Protease Receptor-1 (EPR-1) suggesting a potential for functional interaction between these two proteins.
Factor Xa plays a critical role in the coagulation process by catalyzing the activation of prothrombin to thrombin. It acts on leukocytes, endothelium and smooth muscle cells triggering complex pathways of intracellular signaling. Factor Xa binds to EPR-1. The full length EPR-1 predicts a protein of 337 aa (~65kD de-glycosylated form). EPR-1 is expressed in vascular endothelial cells and smooth muscle cells. Survivin and EPR-1 are encoded by structurally and topographically distinct messages from potentially originating from gene cluster at chromosome 17q25. Overexpression of EPR-1 increased apoptosis and inhibited growth of transformed cells. The importance of the Survivin-EPR-1 interaction remains to be elucidated.
Immunogen: Synthetic 20-aa peptide from human EPR -1. Peptide has no significatn homology with survivin. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing Effector Cell Protease Receptor-1 are readily searchable from our website. Different antibodies against the same target such as Effector Cell Protease Receptor-1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.