anti-RB1 antibody product blogThe RB1 rb1 (Catalog #MBS629832) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Retinoblastoma, phosphorylated (Ser807) (Rb, Retinoblastoma-associated Protein, p105-Rb, pRb, pp110, RB1) reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. MyBioSource\'s Retinoblastoma can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC).
Suitable for use in Western Blot and Immunohistochemistry.
Dilution: Western Blot:1:500-1:1,000
Immunohistochemistry:1:50-1:100. Researchers should empirically determine the suitability of the RB1 rb1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The RB1 rb1 product has the following accession number(s) (GI #29123599) (Uniprot Accession #P06400). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Retinoblastoma, phosphorylated (Ser807) (Rb, Retinoblastoma-associated Protein, p105-Rb, pRb, pp110, RB1)
RB1 likely acts as a regulator of other genes. It forms a complex with adenovirus E1A and with SV40 large T antigen, acts as a tumor suppressor, and may bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding. RB1 is a potent inhibitor of E2F-mediated trans-activation, and also recruits and targets histone methyltransferase SUV39H1 leading to epigenetic transcriptional repression. This protein inhibits the intrinsic kinase activity of TAF1. Defects in RB1 are the cause of childhood cancer retinoblastoma (RB), a congenital malignant tumor that arises from the nuclear layers of the retina. Defects in RB1 are also a cause of bladder cancer and osteogenic sarcoma.
Immunogen: Synthetic phosphopeptide corresponding to human Retinoblastoma around the phosphorylation site of serine 807 (Y-I-SP-P-L). In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing RB1 are readily searchable from our website. Different antibodies against the same target such as RB1 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene. Blood, Bone, Brain, Eye, Intestine, Liver, Lung, Muscle, Prostate, Skin tissues are correlated with this protein. Adenocarcinoma, Breast Neoplasms, Carcinoma, Cell Transformation, Neoplastic, Endocrine Gland Neoplasms, Leukemia, Lymphoma, Neoplasms, Retinoblastoma, Sarcoma are some of the diseases may be linked to Retinoblastoma, phosphorylated (Ser807) (Rb, Retinoblastoma-associated Protein, p105-Rb, pRb, pp110, RB1).