anti-SLX4 antibody product blogThe SLX4 slx4 (Catalog #MBS6012428) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The SLX4 (BTBD12, Structure-specific Endonuclease Subunit SLX4, BTB/POZ Domain-containing Protein 12, KIAA1784, KIAA1987) reacts with Human and may cross-react with other species as described in the data sheet. MyBioSource\'s SLX4 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB).
Suitable for use in Western Blot. Researchers should empirically determine the suitability of the SLX4 slx4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The SLX4 slx4 product has the following accession number(s) (GI #63252863) (NCBI Accession #NP_115820.2) (Uniprot Accession #Q8IY92). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful. The amino acid sequence is listed below:
MVNNPHLSDV QFQTDSGEVL YAHKFVLYAR CPLLIQYVNN EGFSAVEDGV LTQRVLLGDV STEAARTFLH YLYTADTGLP PGLSSELSSL AHRFGVSELV HLCEQVPIAT DSEGKPWEEK EAENCESRAE NFQELLRSMW ADEEEEAETL LKSKDHEEDQ ENVNEAEMEE IYEFAATQRK LLQEERAAGA GEDADWLEGG SPVSGQLLAG VQVQKQWDKV EEMEPLEPGR DEAATTWEKM GQCALPPPQG QHSGARGAEA PEQEAPEEAL GHSSCSSPSR DCQAERKEGS LPHSDDAGDY EQLFSSTQGE ISEPSQITSE PEEQSGAVRE RGLEVSHRLA PWQASPPHPC RFLLGPPQGG SPRGSHHTSG SSLSTPRSRG GTSQVGSPTL LSPAVPSKQK RDRSILTLSK EPGHQKGKER RSVLECRNKG VLMFPEKSLS IDLTQSNPDH SSSRSQKSSS KLNEEDEVIL LLDSDEELEL EQTKMKSISS DPLEEKKALE ISPRSCELFS IIDVDADQEP SQSPPRSEAV LQQEDEGALP ENRGSLGRRG APWLFCDRES SPSEASTTDT SWLVPATPLA SRSRDCSSQT QISSLRSGLA VQAVTQHTPR ASVGNREGNE VAQKFSVIRP QTPPPQTPSS CLTPVSPGTS DGRRQGHRSP SRPHPGGHPH SSPLAPHPIS GDRAHFSRRF LKHSPPGPSF LNQTPAGEVV EVGDSDDEQE VASHQANRSP PLDSDPPIPI DDCCWHMEPL SPIPIDHWNL ERTGPLSTSS PSRRMNEAAD SRDCRSPGLL DTTPIRGSCT TQRKLQEKSS GAGSLGNSRP SFLNSALWDV WDGEEQRPPE TPPPAQMPSA GGAQKPEGLE TPKGANRKKN LPPKVPITPM PQYSIMETPV LKKELDRFGV RPLPKRQMVL KLKEIFQYTH QTLDSDSEDE SQSSQPLLQA PHCQTLASQT YKPSRAGVHA QQEATTGPGA HRPKGPAKTK GPRHQRKHHE SITPPSRSPT KEAPPGLNDD AQIPASQESV ATSVDGSDSS LSSQSSSSCE FGAAFESAGE EEGEGEVSAS QAAVQAADTD EALRCYIRSK PALYQKVLLY QPFELRELQA ELRQNGLRVS SRRLLDFLDT HCITFTTAAT RREKLQGRRR QPRGKKKVER N.
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SLX4 (BTBD12, Structure-specific Endonuclease Subunit SLX4, BTB/POZ Domain-containing Protein 12, KIAA1784, KIAA1987)
Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5\'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3\'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks.
Immunogen: Full length human BTBD12, aa1-1151 (AAH36335). In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing SLX4 are readily searchable from our website. Different antibodies against the same target such as SLX4 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results.