anti-STAT3 antibody product blogThe STAT3 stat3 (Catalog #MBS6002480) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The STAT3, phosphorylated (Tyr705) (Signal Transducer and Activator of Transcription 3, Acute-phase Response Factor, APRF, FLJ20882, MGC16063) reacts with Canine, Human, Mouse and may cross-react with other species as described in the data sheet. MyBioSource\'s STAT3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB).
Suitable for use in Western Blot.
Dilution: Western Blot: 0.1-0.5ug/ml. Researchers should empirically determine the suitability of the STAT3 stat3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
The STAT3 stat3 product has the following accession number(s) (GI #21618340) (NCBI Accession #NP_644805.1) (Uniprot Accession #P40763). Researchers may be interested in using Bioinformatics databases such as those available at The National Center for Biotechnology Information (NCBI) website for more information about accession numbers and the proteins they represent. Even researchers unfamiliar with bioinformatics databases will find the NCBI databases to be quite user friendly and useful.
To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
STAT3, phosphorylated (Tyr705) (Signal Transducer and Activator of Transcription 3, Acute-phase Response Factor, APRF, FLJ20882, MGC16063)
The STAT family is a group of cytoplasmic latent transcription factors that are activated to regulate gene expression in response to a large number of extracellular signaling polypeptides including cytokines, interferons, and growth factors. After phosphorylation by JAK tyrosine kinases, STATs enter the nucleus to regulate transcription of many different genes. Among the seven STATs (STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, and STAT6), STAT1, STAT3, STAT5a, and STAT5b have a wide activation profile (1,2). STAT1 and STAT3 can be activated simultaneously by the interactions of cells with the same polypeptide ligand. STAT3 is a transcription factor that binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. It is activated by IL-31 through IL-31RA. STAT3 is known to express in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Defects in STAT3 are the cause of hyperimmunoglobulin E recurrent infection syndrome autosomal dominant (AD-HIES), also known as hyper-IgE syndrome or Job syndrome.
Immunogen: Synthetic peptide corresponding to human STAT3 protein containing a phosphorylated tyrosine residue at position 705. In general, we may offer more than one antibody to a given target to enable options for the researcher. Available antibodies recognizing STAT3 are readily searchable from our website. Different antibodies against the same target such as STAT3 may be optimized or tested for different applications and species. This enables researchers to select the option that may be best for their model system, to screen more than antibody to determine which one may be best for their model system, as well as to use more than one antibody to follow up on and validate their results. The following patways have been known to be associated with this gene.